Racemethionine in organ protection

  • Endothelial protection in Cardiovascular disorders and diabetes -Oxidant stress is a causative factor of endothelial dysfunction and plays an important role in the pathophysiology of several vascular diseases such as atherosclerosis, diabetes, or neurodegenerative diseases.

  • L-methionine shows antioxidant properties in various models of oxidative stress. Antioxidant effects of L-methionine lead to the reduction of lipid peroxidation, protection against membrane damage and to restoration of changes in the glutathione system. Methionine residues can act as powerful endogenous antioxidants in proteins.

  • L-methionine led to a concentration-dependent induction of the antioxidant proteins heme oxygenase-1 (HO-1) and ferritin in cultured endothelial cells. These substances provide cytoprotection and prevent endothelial damages in atherosclerosis, diabetes and other disorders.4

Brain Functions :-

  • Methionine is used to treat depression and improves memory recall. People suffering from schizophrenia could be benefited from methionine since it reduces the level of histidine in the body, a level normally higher in people suffering from schizophrenia.

  • SAMe formed from methionine is beneficial for most forms of depression. SAMe may boost the activity of several brain chemicals involved in mood, such as norepinephrine, dopamine, and serotonin.

  • Methionine and SAMe are essential for the regeneration of neuron axons following injury, and for the formation of myelin sheaths (a fatty substance) that surround axons. Alzheimer's and Parkinson's patients have very low levels of SAMe, and methionine supplementation may help treat some symptoms of Parkinson's disease.

Joints and muscles :-

  • SAMe relieves arthritic pain. It has a protective effect on joints and repairs cartilage. SAMe has been shown to be effective as a treatment for osteoarthritis and associated joint pain, stiffness, and inflammation.

  • It is needed to manufacture creatine monohydrate, a compound essential for energy production and muscle building.

  • Methionine is also responsible in lowering the amount of inflammatory histamines. It is beneficial for patients with cases of chronic allergies and arthritis, to take supplemental methionine.

Pancreas :-

  • Methionine in combination with several antioxidants may reduce pain and recurrences of attacks of pancreatitis (inflammation of the pancreas).

Liver protection :-

  • Cells in the liver and kidneys especially need methionine for regeneration. It helps protects against the destruction of delicate liver tissues.

  • Methionine helps maintain the health of the liver by removing toxins and giving protection.

  • Methionine levels determine the liver's concentration of sulfur-containing antioxidant compounds like SAMe and glutathione which improve and normalize liver functions.

  • Methionine itself has a protective effect on glutathione and prevents depletion during toxic overload, which can protect the liver from the damaging effects of toxic compounds.5

  • Methionine residues on the surface of proteins (like enzymes) offer antioxidant protection and thus prevent degradation of proteins by reactive oxygen species and free radicals. Liver contains maximum amounts of enzymes and thus methionine concentration in liver is important for protection against toxic free radicals.6

Alcoholic liver disorders :-

  • Alcohol is a major cause of liver disease and disrupts methionine and oxidative balances.

  • Alcohol feeding to rats that were submitted to a jejunoileal bypass operation has been shown to result in liver damage being comparable with alcohol-induced liver disease in man. In a study, a striking effect of free methionine consumption on histological liver injury, triglyceride accumulation, and energy-rich nucleoside content in the liver of rats with a jejunoileal bypass is demonstrated. Methionine was found to strongly improve the alcohol-induced histological changes in the liver. Triglyceride content of the liver was found to decrease in a dose-dependent manner with increasing methionine ingestion. Hepatic adenosine triphosphate content increased significantly with higher methionine consumption. These results underscore the impairment of the transmethylation/transsulfuration pathway in the development of alcohol-induced liver diseases.7

Liver detoxification :-

  • Methionine helps to detoxify harmful agents such as lead and other heavy metals.

Drug induced toxicity :-

  • Acetaminophen toxicity- Racemethionine may protect against acetaminophen overdose induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. Glutathione is required to inactivate an intermediate metabolite of acetaminophen, which is hepatotoxic. Racemethionine serves as a precursor for the synthesis of glutathione and sulfate.
                       Methionine is the precursor for other important antioxidant substances like SAMe and glutathione.