Taurine In Alcoholic Liver Disorders

  • Taurine reverses the hepatic steatosis (deposition of fat) and lipid peroxidation caused by chronic alcohol consumption in rats.

  • Taurine has been shown to be useful in treating people with alcohol dependency. A study involving over 3,000 alcohol dependent people who were given taurine showed that taurine is more effective than placebo at preventing alcohol relapse.

  • Taurine increases urine excretion of homocysteine during alcohol withdrawal. Rise in blood homocysteine (hyperhomocysteinaemia) was observed in chronic alcoholics who underwent withdrawal from alcohol. Homocysteine has excitatory effects in brain and is associated with nervous restlessness and other psychotic episodes seen during alcohol withdrawal. Taurine being an inhibitory neurotransmitter reduces excitatory signals. It also reduces hyperhomocysteinaemia by excreting homocysteine through kidneys. This dual effect helps in alcohol withdrawal.

  • Twenty-two patients undergoing treatment for alcohol withdrawal were given 1 gram of taurine three times per day orally for seven days. When compared to retrospective controls, significantly fewer of the taurine-treated patients had psychotic episodes (14% vs. 45%, p < 0.05). The number of psychotic cases after admission who had also been psychotic before admission was 1/16 for the taurine group and 11/17 for the controls (p < 0.001).10

  • The inhibitory amino acid taurine may constitute an important protective mechanism against excitotoxicity and thus protects against neuronal damage.

Dosage Recommendations :-

  • Most reputable authorities suggest 500mg-3,000mg per day as the standard dosage. However, dosages up to 6,000mg have been seen in cardiac patients trying to lower blood pressure.

Safety Of Taurine :-

  • Human and animal studies have demonstrated overwhelmingly that taurine is a safe – and beneficial – supplement.